Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0297	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0297	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0298	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	imiquimod leads to decreased tyrosinase and MITF expression and is accompanied by decreased pigmentation.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Melanocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	It inhibits Melanogenesis and Proliferation of Human Melanocytes.	NA	18596825	2008	Pubchem Assay
PRRID_0298	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	imiquimod leads to decreased tyrosinase and MITF expression and is accompanied by decreased pigmentation.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Melanocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	It inhibits Melanogenesis and Proliferation of Human Melanocytes.	NA	18596825	2008	Pubchem Assay
PRRID_0299	Imiquimod (R837) Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0299	Imiquimod (R837) Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0324	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	NA	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0324	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	NA	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0334	poly(A:U) Click for more detail	synthetic oligonucleotide (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	17981792	2008	NA
PRRID_0334	poly(A:U) Click for more detail	synthetic oligonucleotide (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	17981792	2008	NA
PRRID_0335	poly(A:U) Click for more detail	synthetic oligonucleotide (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	17981792	2008	NA
PRRID_0335	poly(A:U) Click for more detail	synthetic oligonucleotide (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	17981792	2008	NA
PRRID_0336	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	They produce the proinflammatory molecule ICAM1 and secrete functionally active CCL2 chemokine.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Sertoli cells	LRR	Q99MB1.fasta	Q99MB1	905	Poly (I:C) elicits both inflammatory and antiviral responses in Sertoli cells.	ELISA	18596219	2008	Pubchem Assay
PRRID_0336	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	They produce the proinflammatory molecule ICAM1 and secrete functionally active CCL2 chemokine.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Sertoli cells	LRR	Q99MB1.fasta	Q99MB1	905	Poly (I:C) elicits both inflammatory and antiviral responses in Sertoli cells.	ELISA	18596219	2008	Pubchem Assay
PRRID_0337	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Salmo salar L.	Spleen and head kidney	NA	NA	NA	NA	It resulted into viral recognition, resulting in an enhanced innate immune response.	NA	18602433	2008	NA
PRRID_0337	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Salmo salar L.	Spleen and head kidney	NA	NA	NA	NA	It resulted into viral recognition, resulting in an enhanced innate immune response.	NA	18602433	2008	NA
PRRID_0338	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Stilmulation leads to the activation of the NF-KappaB.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Primary Human Keratinocytes	NA	O15455.fasta	O15455	904	It is responsible for the antiviral defense status.	ELISA	18684960	2008	Pubchem Assay
PRRID_0338	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Stilmulation leads to the activation of the NF-KappaB.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Primary Human Keratinocytes	NA	O15455.fasta	O15455	904	It is responsible for the antiviral defense status.	ELISA	18684960	2008	Pubchem Assay
PRRID_0339	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Stilmulation leads to the activation of the IRF3.	Protein Kinase R (PKR)	Cytosolic receptor	Human	Primary Human Keratinocytes	NA	NA	NA	NA	It is responsible for the antiviral defense status.	ELISA	18684960	2008	NA
PRRID_0339	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Stilmulation leads to the activation of the IRF3.	Protein Kinase R (PKR)	Cytosolic receptor	Human	Primary Human Keratinocytes	NA	NA	NA	NA	It is responsible for the antiviral defense status.	ELISA	18684960	2008	NA
PRRID_0340	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Stilmulation leads to the activation of the IRF3.	RIG-1	Rig-like receptor (RLR)	Human	Primary Human Keratinocytes	NA	O95786.fasta	O95786	925	It is responsible for the antiviral defense status.	ELISA	18684960	2008	Pubchem Assay
PRRID_0340	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Stilmulation leads to the activation of the IRF3.	RIG-1	Rig-like receptor (RLR)	Human	Primary Human Keratinocytes	NA	O95786.fasta	O95786	925	It is responsible for the antiviral defense status.	ELISA	18684960	2008	Pubchem Assay
PRRID_0341	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Stilmulation leads to the activation of the IRF3 and NF-	MDA5	Rig-like receptor (RLR)	Human	Primary Human Keratinocytes	NA	Q53TB6.fasta	Q53TB6	435	It is responsible for the antiviral defense status.	ELISA	18684960	2008	Pubchem Assay
PRRID_0341	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Stilmulation leads to the activation of the IRF3 and NF-	MDA5	Rig-like receptor (RLR)	Human	Primary Human Keratinocytes	NA	Q53TB6.fasta	Q53TB6	435	It is responsible for the antiviral defense status.	ELISA	18684960	2008	Pubchem Assay
PRRID_0342	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Mesothelial cells	NA	O15455.fasta	O15455	904	It leads to the inflammation and infection of mesothelial cells.	ELISA	19005739	2008	Pubchem Assay
PRRID_0342	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Mesothelial cells	NA	O15455.fasta	O15455	904	It leads to the inflammation and infection of mesothelial cells.	ELISA	19005739	2008	Pubchem Assay
PRRID_0343	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.	RIG-1	Rig-like receptor (RLR)	Human	Mesothelial cells	NA	O95786.fasta	O95786	925	It leads to the inflammation and infection of mesothelial cells.	ELISA	19005739	2008	Pubchem Assay
PRRID_0343	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.	RIG-1	Rig-like receptor (RLR)	Human	Mesothelial cells	NA	O95786.fasta	O95786	925	It leads to the inflammation and infection of mesothelial cells.	ELISA	19005739	2008	Pubchem Assay
PRRID_0344	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.	MDA5	Rig-like receptor (RLR)	Human	Mesothelial cells	NA	Q53TB6.fasta	Q53TB6	435	It leads to the inflammation and infection of mesothelial cells.	ELISA	19005739	2008	Pubchem Assay
PRRID_0344	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.	MDA5	Rig-like receptor (RLR)	Human	Mesothelial cells	NA	Q53TB6.fasta	Q53TB6	435	It leads to the inflammation and infection of mesothelial cells.	ELISA	19005739	2008	Pubchem Assay
PRRID_0346	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	epithelial cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0346	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	epithelial cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0347	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	epithelial cells	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0347	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	epithelial cells	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0354	Viral RNA Click for more detail	Murine norovirus-1 (virus)	NA	NA	Nucleic Acid	Natural	Upon stimulation, it leads to the production of IFN-alpha, IL-6, MCP-1, TNFalpha and IFN-beta.	MDA5	Rig-like receptor (RLR)	Mice	Bone marrow-derived DC	NA	Q8R5F7.fasta	Q8R5F7	1025	MDA5 limits MNV-1 replication.	ELISA	18636103	2008	Pubchem Assay
PRRID_0354	Viral RNA Click for more detail	Murine norovirus-1 (virus)	NA	NA	Nucleic Acid	Natural	Upon stimulation, it leads to the production of IFN-alpha, IL-6, MCP-1, TNFalpha and IFN-beta.	MDA5	Rig-like receptor (RLR)	Mice	Bone marrow-derived DC	NA	Q8R5F7.fasta	Q8R5F7	1025	MDA5 limits MNV-1 replication.	ELISA	18636103	2008	Pubchem Assay
PRRID_0377	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly (I:C) induces the generation of IRF3-dependent type I IFN and triggers the activation of the Rho GTPase RhoA, which leads to the activation of NF-kappaB.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	lung epithelial cells (small airway lung epithelial (SALE))	NA	O15455.fasta	O15455	904	This induces the inflammatory response.	NF-kappaB-luciferase reporter assays	19265130	2009	Pubchem Assay
PRRID_0377	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly (I:C) induces the generation of IRF3-dependent type I IFN and triggers the activation of the Rho GTPase RhoA, which leads to the activation of NF-kappaB.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	lung epithelial cells (small airway lung epithelial (SALE))	NA	O15455.fasta	O15455	904	This induces the inflammatory response.	NF-kappaB-luciferase reporter assays	19265130	2009	Pubchem Assay
PRRID_0379	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0379	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0380	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0380	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0381	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0381	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0382	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0382	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0383	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0383	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0384	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0384	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0385	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0385	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0386	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NYK1.fasta	Q9NYK1	1049	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0386	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NYK1.fasta	Q9NYK1	1049	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0387	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	PBMCs	NA	NA	NA	NA	This induces the inflammatory response.	PBMC assay	19269175	2009	NA
PRRID_0387	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	PBMCs	NA	NA	NA	NA	This induces the inflammatory response.	PBMC assay	19269175	2009	NA
PRRID_0388	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	pDCs	NA	NA	NA	NA	This induces the inflammatory response.	NA	19269175	2009	NA
PRRID_0388	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	pDCs	NA	NA	NA	NA	This induces the inflammatory response.	NA	19269175	2009	NA
PRRID_0389	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	On stimulation, production of significant amount of IL-12, KC, and IP-10 takes place.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	Macropahges	NA	NA	NA	NA	This induces the inflammatory response.	cell-based assays	19269175	2009	NA
PRRID_0389	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	On stimulation, production of significant amount of IL-12, KC, and IP-10 takes place.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	Macropahges	NA	NA	NA	NA	This induces the inflammatory response.	cell-based assays	19269175	2009	NA
PRRID_0390	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0390	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0391	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0391	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0392	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0392	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0393	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0393	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0394	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0394	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0395	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0395	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0396	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0396	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0397	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0397	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0398	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0398	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0400	Viral Genome Click for more detail	Rabies virus (virus)	NA	NA	Nucleic Acid	Natural	Rabies genome is a potent activator of TLR3	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Neuronal cells	NA	O15455.fasta	O15455	904	TLR3 is involved in the spatial arrangement of rabies virus‚Äìinduced NBs and viral replication.	NA	19247444	2009	Pubchem Assay
PRRID_0400	Viral Genome Click for more detail	Rabies virus (virus)	NA	NA	Nucleic Acid	Natural	Rabies genome is a potent activator of TLR3	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Neuronal cells	NA	O15455.fasta	O15455	904	TLR3 is involved in the spatial arrangement of rabies virus‚Äìinduced NBs and viral replication.	NA	19247444	2009	Pubchem Assay
PRRID_0402	3pRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of IFN-	RIG-1	Rig-like receptor (RLR)	Human	NK cells	NA	O95786.fasta	O95786	925	It resulted in direct activation NK cells leading to high IFN-Œ≥ production in synergy with mDC-released soluble mediators induced by dsRNA	NA	20639488	2010	Pubchem Assay
PRRID_0402	3pRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of IFN-	RIG-1	Rig-like receptor (RLR)	Human	NK cells	NA	O95786.fasta	O95786	925	It resulted in direct activation NK cells leading to high IFN-Œ≥ production in synergy with mDC-released soluble mediators induced by dsRNA	NA	20639488	2010	Pubchem Assay
PRRID_0403	5'-triphosphated RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	RIG-1	Rig-like receptor (RLR)	Mice (Murine)	Cytoplasm	NA	Q6Q899.fasta	Q6Q899	926	NA	NA	20739519	2010	Pubchem Assay
PRRID_0403	5'-triphosphated RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	RIG-1	Rig-like receptor (RLR)	Mice (Murine)	Cytoplasm	NA	Q6Q899.fasta	Q6Q899	926	NA	NA	20739519	2010	Pubchem Assay
PRRID_0413	ATP Click for more detail	Injured cell (others)	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Nucleic Acid	Natural	Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤ and IL-18.	P2	Purinergic Receptor	Endogenous	NA	NA	NA	NA	NA	It leads to the inflammation of the cell	NA	20740341	2010	NA
PRRID_0413	ATP Click for more detail	Injured cell (others)	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Nucleic Acid	Natural	Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤ and IL-18.	P2	Purinergic Receptor	Endogenous	NA	NA	NA	NA	NA	It leads to the inflammation of the cell	NA	20740341	2010	NA
PRRID_0426	Bacterial DNA Click for more detail	Porphyromonas gingivalis and Tannerella forsythia (Bacteria)	NA	NA	Nucleic Acid	Natural	It induces the release of IL-8 , IL-1beta, IL-6 TNF-alpha, and NF-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Monocytic cells (THP-1 cells)	LRR	Q9NR96.fasta	Q9NR96	1032	Immune responses triggered by periodontal bacterial nucleic acids mediated by inducing proinflammatory cytokine production through the TLR9 signaling pathway.	ELISA	20331800	2010	Pubchem Assay
PRRID_0426	Bacterial DNA Click for more detail	Porphyromonas gingivalis and Tannerella forsythia (Bacteria)	NA	NA	Nucleic Acid	Natural	It induces the release of IL-8 , IL-1beta, IL-6 TNF-alpha, and NF-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Monocytic cells (THP-1 cells)	LRR	Q9NR96.fasta	Q9NR96	1032	Immune responses triggered by periodontal bacterial nucleic acids mediated by inducing proinflammatory cytokine production through the TLR9 signaling pathway.	ELISA	20331800	2010	Pubchem Assay
PRRID_0427	Bform dsDNA Click for more detail	HCMV (virus)	NA	NA	Nucleic Acid	Natural	It leads to the activation of IRF3, which participate in the induction of IFN-Œ≤ expression	ZBP-1 or DAI	DNA Receptor	NA	NA	NA	NA	NA	NA	It results into the anti-viral response by the immune system of host	NA	20620129	2010	NA
PRRID_0427	Bform dsDNA Click for more detail	HCMV (virus)	NA	NA	Nucleic Acid	Natural	It leads to the activation of IRF3, which participate in the induction of IFN-Œ≤ expression	ZBP-1 or DAI	DNA Receptor	NA	NA	NA	NA	NA	NA	It results into the anti-viral response by the immune system of host	NA	20620129	2010	NA
PRRID_0429	BV-nucleic acid Click for more detail	Baculovirus(virus)	NA	NA	Nucleic Acid	Natural	It leads to increased expression of cytokine IL-12 p40	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	Macrophage-like cell line (HD11)	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	This results into the inflammatory response, which leads to clearance of pathogen	NA	20471186	2010	NA
PRRID_0429	BV-nucleic acid Click for more detail	Baculovirus(virus)	NA	NA	Nucleic Acid	Natural	It leads to increased expression of cytokine IL-12 p40	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	Macrophage-like cell line (HD11)	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	This results into the inflammatory response, which leads to clearance of pathogen	NA	20471186	2010	NA
PRRID_0435	CL097 Click for more detail	derivative of the imidazoquinoline compound R848(others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	The binding induces the production of IL-6, IL-10, TNF-‚ç∫ and IL-23	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	Lamina propria DCs obtained from the human GI tract	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It induces intestinal inflammation and potentially alter the homeostatic response to commensal flora	NA	20483758	2010	NA
PRRID_0435	CL097 Click for more detail	derivative of the imidazoquinoline compound R848(others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	The binding induces the production of IL-6, IL-10, TNF-‚ç∫ and IL-23	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	Lamina propria DCs obtained from the human GI tract	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It induces intestinal inflammation and potentially alter the homeostatic response to commensal flora	NA	20483758	2010	NA
PRRID_0443	CpG DNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0443	CpG DNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0444	CpG DNA motifs Click for more detail	Virus, Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Inflammation	NA	20692289	2010	NA
PRRID_0444	CpG DNA motifs Click for more detail	Virus, Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Inflammation	NA	20692289	2010	NA
PRRID_0445	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0445	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay

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